Pharmacokinetic variability and exposures of fluconazole, anidulafungin, and caspofungin in intensive care unit patients: Data from multinational Defining Antibiotic Levels in Intensive care unit (DALI) patients Study
Identifieur interne : 002A22 ( Main/Exploration ); précédent : 002A21; suivant : 002A23Pharmacokinetic variability and exposures of fluconazole, anidulafungin, and caspofungin in intensive care unit patients: Data from multinational Defining Antibiotic Levels in Intensive care unit (DALI) patients Study
Auteurs : Mahipal G. Sinnollareddy [Australie] ; Jason A. Roberts [Australie] ; Jeffrey Lipman [Australie] ; Murat Akova [Turquie] ; Matteo Bassetti [Italie] ; Jan J. De Waele [Belgique] ; Kirsi-Maija Kaukonen [Finlande] ; Despoina Koulenti [Australie, Grèce] ; Claude Martin [France] ; Philippe Montravers [France] ; Jordi Rello [Espagne] ; Andrew Rhodes [Royaume-Uni] ; Therese Starr [Australie] ; Steven C. Wallis [Australie] ; George Dimopoulos [Grèce]Source :
- Critical Care [ 1364-8535 ] ; 2015.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Antifongiques (pharmacocinétique), Antifongiques (usage thérapeutique), Europe, Femelle, Fluconazole (pharmacocinétique), Fluconazole (usage thérapeutique), Humains, Lipopeptides, Maladie grave (), Mâle, Sujet âgé, Surveillance pharmacologique, Unités de soins intensifs, Échinocandines (pharmacocinétique), Échinocandines (usage thérapeutique).
- MESH :
- pharmacocinétique : Antifongiques, Fluconazole, Échinocandines.
- usage thérapeutique : Antifongiques, Fluconazole, Échinocandines.
- Adulte d'âge moyen, Europe, Femelle, Humains, Lipopeptides, Maladie grave, Mâle, Sujet âgé, Surveillance pharmacologique, Unités de soins intensifs.
English descriptors
- KwdEn :
- Aged, Antifungal Agents (pharmacokinetics), Antifungal Agents (therapeutic use), Critical Illness (therapy), Drug Monitoring, Echinocandins (pharmacokinetics), Echinocandins (therapeutic use), Europe, Female, Fluconazole (pharmacokinetics), Fluconazole (therapeutic use), Humans, Intensive Care Units, Lipopeptides, Male, Middle Aged.
- MESH :
- chemical , pharmacokinetics : Antifungal Agents, Echinocandins, Fluconazole.
- chemical , therapeutic use : Antifungal Agents, Echinocandins, Fluconazole.
- therapy : Critical Illness.
- Aged, Drug Monitoring, Europe, Female, Humans, Intensive Care Units, Lipopeptides, Male, Middle Aged.
Abstract
The objective of the study was to describe the pharmacokinetics (PK) of fluconazole, anidulafungin, and caspofungin in critically ill patients and to compare with previously published data. We also sought to determine whether contemporary fluconazole doses achieved PK/pharmacodynamic (PD; PK/PD) targets in this cohort of intensive care unit patients.
The Defining Antibiotic Levels in Intensive care unit patients (DALI) study was a prospective, multicenter point-prevalence PK study. Sixty-eight intensive care units across Europe participated. Inclusion criteria were met by critically ill patients administered fluconazole (
The mean age, weight, and Acute Physiology and Chronic Health Evaluation (APACHE) II scores of the included patients were 58 years, 84 kg, and 22, respectively. Fluconazole, caspofungin, and anidulafungin showed large interindividual variability in this study. In patients receiving fluconazole, 33% did not attain the PK/PD target, ratio of free drug area under the concentration-time curve from 0 to 24 hours to minimum inhibitory concentration (
Considerable interindividual variability was observed for fluconazole, anidulafungin, and caspofungin. A large proportion of the patients (33%) receiving fluconazole did not attain the PK/PD target, which might be related to inadequate dosing. For anidulafungin and caspofungin, dose optimization also appears necessary to minimize variability.
The online version of this article (doi:10.1186/s13054-015-0758-3) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1186/s13054-015-0758-3
PubMed: 25888060
PubMed Central: 4335513
Affiliations:
- Australie, Belgique, Espagne, Finlande, France, Grèce, Italie, Royaume-Uni, Turquie
- Angleterre, Attique (région), Catalogne, Provence-Alpes-Côte d'Azur, Île-de-France
- Athènes, Barcelone, Marseille, Paris
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Le document en format XML
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Sinnollareddy</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Burns Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Burns Trauma and Critical Care Research Centre, The University of Queensland, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2">School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>School of Pharmacy and Medical Sciences, University of South Australia, Adelaide</wicri:regionArea><wicri:noRegion>Adelaide</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff3">Therapeutics Research Centre, Basil Hetzel Institute for Translational Health Research, The Queen Elizabeth Hospital, Adelaide, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Therapeutics Research Centre, Basil Hetzel Institute for Translational Health Research, The Queen Elizabeth Hospital, Adelaide</wicri:regionArea><wicri:noRegion>Adelaide</wicri:noRegion></affiliation></author><author><name sortKey="Roberts, Jason A" sort="Roberts, Jason A" uniqKey="Roberts J" first="Jason A" last="Roberts">Jason A. Roberts</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Burns Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Burns Trauma and Critical Care Research Centre, The University of Queensland, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff4">Royal Brisbane and Women’s Hospital, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Royal Brisbane and Women’s Hospital, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Lipman, Jeffrey" sort="Lipman, Jeffrey" uniqKey="Lipman J" first="Jeffrey" last="Lipman">Jeffrey Lipman</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Burns Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Burns Trauma and Critical Care Research Centre, The University of Queensland, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff4">Royal Brisbane and Women’s Hospital, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Royal Brisbane and Women’s Hospital, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Akova, Murat" sort="Akova, Murat" uniqKey="Akova M" first="Murat" last="Akova">Murat Akova</name><affiliation wicri:level="1"><nlm:aff id="Aff5">School of Medicine, Hacettepe University, Ankara, Turkey</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>School of Medicine, Hacettepe University, Ankara</wicri:regionArea><wicri:noRegion>Ankara</wicri:noRegion></affiliation></author><author><name sortKey="Bassetti, Matteo" sort="Bassetti, Matteo" uniqKey="Bassetti M" first="Matteo" last="Bassetti">Matteo Bassetti</name><affiliation wicri:level="1"><nlm:aff id="Aff6">Azienda Ospedaliera Universitaria Santa Maria della Misericordia, Udine, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Azienda Ospedaliera Universitaria Santa Maria della Misericordia, Udine</wicri:regionArea><wicri:noRegion>Udine</wicri:noRegion></affiliation></author><author><name sortKey="De Waele, Jan J" sort="De Waele, Jan J" uniqKey="De Waele J" first="Jan J" last="De Waele">Jan J. De Waele</name><affiliation wicri:level="1"><nlm:aff id="Aff7">Ghent University Hospital, Ghent, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Ghent University Hospital, Ghent</wicri:regionArea><wicri:noRegion>Ghent</wicri:noRegion></affiliation></author><author><name sortKey="Kaukonen, Kirsi Maija" sort="Kaukonen, Kirsi Maija" uniqKey="Kaukonen K" first="Kirsi-Maija" last="Kaukonen">Kirsi-Maija Kaukonen</name><affiliation wicri:level="1"><nlm:aff id="Aff8">Helsinki University Central Hospital, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Helsinki University Central Hospital, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Koulenti, Despoina" sort="Koulenti, Despoina" uniqKey="Koulenti D" first="Despoina" last="Koulenti">Despoina Koulenti</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Burns Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Burns Trauma and Critical Care Research Centre, The University of Queensland, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff9">Attikon University Hospital, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Attikon University Hospital, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Martin, Claude" sort="Martin, Claude" uniqKey="Martin C" first="Claude" last="Martin">Claude Martin</name><affiliation wicri:level="3"><nlm:aff id="Aff10">Hospital Nord, Marseille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Hospital Nord, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff11">AzuRea Group, Antibes, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>AzuRea Group, Antibes</wicri:regionArea><wicri:noRegion>Antibes</wicri:noRegion><wicri:noRegion>Antibes</wicri:noRegion></affiliation></author><author><name sortKey="Montravers, Philippe" sort="Montravers, Philippe" uniqKey="Montravers P" first="Philippe" last="Montravers">Philippe Montravers</name><affiliation wicri:level="3"><nlm:aff id="Aff12">Centre Hospitalier Universitaire Bichat-Claude Bernard, AP-HP, Université Paris VII, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Universitaire Bichat-Claude Bernard, AP-HP, Université Paris VII, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Rello, Jordi" sort="Rello, Jordi" uniqKey="Rello J" first="Jordi" last="Rello">Jordi Rello</name><affiliation wicri:level="3"><nlm:aff id="Aff13">CIBERES, Vall d’Hebron Institute of Research, Universitat Autonoma de Barcelona, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBERES, Vall d’Hebron Institute of Research, Universitat Autonoma de Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Rhodes, Andrew" sort="Rhodes, Andrew" uniqKey="Rhodes A" first="Andrew" last="Rhodes">Andrew Rhodes</name><affiliation wicri:level="2"><nlm:aff id="Aff14">St George’s Healthcare NHS Trust and St George’s University of London, London, England</nlm:aff><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>St George’s Healthcare NHS Trust and St George’s University of London, London</wicri:cityArea></affiliation></author><author><name sortKey="Starr, Therese" sort="Starr, Therese" uniqKey="Starr T" first="Therese" last="Starr">Therese Starr</name><affiliation wicri:level="1"><nlm:aff id="Aff4">Royal Brisbane and Women’s Hospital, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Royal Brisbane and Women’s Hospital, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Wallis, Steven C" sort="Wallis, Steven C" uniqKey="Wallis S" first="Steven C" last="Wallis">Steven C. Wallis</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Burns Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Burns Trauma and Critical Care Research Centre, The University of Queensland, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Dimopoulos, George" sort="Dimopoulos, George" uniqKey="Dimopoulos G" first="George" last="Dimopoulos">George Dimopoulos</name><affiliation wicri:level="3"><nlm:aff id="Aff9">Attikon University Hospital, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Attikon University Hospital, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author></analytic><series><title level="j">Critical Care</title><idno type="ISSN">1364-8535</idno><idno type="eISSN">1466-609X</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Antifungal Agents (pharmacokinetics)</term><term>Antifungal Agents (therapeutic use)</term><term>Critical Illness (therapy)</term><term>Drug Monitoring</term><term>Echinocandins (pharmacokinetics)</term><term>Echinocandins (therapeutic use)</term><term>Europe</term><term>Female</term><term>Fluconazole (pharmacokinetics)</term><term>Fluconazole (therapeutic use)</term><term>Humans</term><term>Intensive Care Units</term><term>Lipopeptides</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Antifongiques (pharmacocinétique)</term><term>Antifongiques (usage thérapeutique)</term><term>Europe</term><term>Femelle</term><term>Fluconazole (pharmacocinétique)</term><term>Fluconazole (usage thérapeutique)</term><term>Humains</term><term>Lipopeptides</term><term>Maladie grave ()</term><term>Mâle</term><term>Sujet âgé</term><term>Surveillance pharmacologique</term><term>Unités de soins intensifs</term><term>Échinocandines (pharmacocinétique)</term><term>Échinocandines (usage thérapeutique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Antifungal Agents</term><term>Echinocandins</term><term>Fluconazole</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antifungal Agents</term><term>Echinocandins</term><term>Fluconazole</term></keywords><keywords scheme="MESH" qualifier="pharmacocinétique" xml:lang="fr"><term>Antifongiques</term><term>Fluconazole</term><term>Échinocandines</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Critical Illness</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antifongiques</term><term>Fluconazole</term><term>Échinocandines</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Drug Monitoring</term><term>Europe</term><term>Female</term><term>Humans</term><term>Intensive Care Units</term><term>Lipopeptides</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Europe</term><term>Femelle</term><term>Humains</term><term>Lipopeptides</term><term>Maladie grave</term><term>Mâle</term><term>Sujet âgé</term><term>Surveillance pharmacologique</term><term>Unités de soins intensifs</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Introduction</title><p>The objective of the study was to describe the pharmacokinetics (PK) of fluconazole, anidulafungin, and caspofungin in critically ill patients and to compare with previously published data. We also sought to determine whether contemporary fluconazole doses achieved PK/pharmacodynamic (PD; PK/PD) targets in this cohort of intensive care unit patients.</p></sec><sec><title>Methods</title><p>The Defining Antibiotic Levels in Intensive care unit patients (DALI) study was a prospective, multicenter point-prevalence PK study. Sixty-eight intensive care units across Europe participated. Inclusion criteria were met by critically ill patients administered fluconazole (<italic>n</italic> = 15), anidulafungin (<italic>n</italic> = 9), and caspofungin (<italic>n</italic> = 7). Three blood samples (peak, mid-dose, and trough) were collected for PK/PD analysis. PK analysis was performed by using a noncompartmental approach.</p></sec><sec><title>Results</title><p>The mean age, weight, and Acute Physiology and Chronic Health Evaluation (APACHE) II scores of the included patients were 58 years, 84 kg, and 22, respectively. Fluconazole, caspofungin, and anidulafungin showed large interindividual variability in this study. In patients receiving fluconazole, 33% did not attain the PK/PD target, ratio of free drug area under the concentration-time curve from 0 to 24 hours to minimum inhibitory concentration (<italic>f</italic>AUC<sub>0–24</sub>/MIC) ≥100. The fluconazole dose, described in milligrams per kilogram, was found to be significantly associated with achievement of <italic>f</italic>AUC<sub>0–24</sub>/MIC ≥100 (<italic>P</italic> = 0.0003).</p></sec><sec><title>Conclusions</title><p>Considerable interindividual variability was observed for fluconazole, anidulafungin, and caspofungin. A large proportion of the patients (33%) receiving fluconazole did not attain the PK/PD target, which might be related to inadequate dosing. For anidulafungin and caspofungin, dose optimization also appears necessary to minimize variability.</p></sec><sec><title>Electronic supplementary material</title><p>The online version of this article (doi:10.1186/s13054-015-0758-3) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Eggimann, P" uniqKey="Eggimann P">P Eggimann</name></author><author><name sortKey="Garbino, J" uniqKey="Garbino J">J Garbino</name></author><author><name sortKey="Pittet, D" uniqKey="Pittet D">D Pittet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vincent, Jl" uniqKey="Vincent J">JL Vincent</name></author><author><name sortKey="Rello, J" uniqKey="Rello J">J Rello</name></author><author><name sortKey="Marshall, J" uniqKey="Marshall J">J Marshall</name></author><author><name sortKey="Silva, E" uniqKey="Silva E">E 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Buijk</name></author><author><name sortKey="Gyssens, Ic" uniqKey="Gyssens I">IC Gyssens</name></author><author><name sortKey="Mouton, Jw" uniqKey="Mouton J">JW Mouton</name></author><author><name sortKey="Verbrugh, Ha" uniqKey="Verbrugh H">HA Verbrugh</name></author><author><name sortKey="Touw, Dj" uniqKey="Touw D">DJ Touw</name></author><author><name sortKey="Bruining, Ha" uniqKey="Bruining H">HA Bruining</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sobue, S" uniqKey="Sobue S">S Sobue</name></author><author><name sortKey="Tan, K" uniqKey="Tan K">K Tan</name></author><author><name sortKey="Layton, G" uniqKey="Layton G">G Layton</name></author><author><name sortKey="Eve, M" uniqKey="Eve M">M Eve</name></author><author><name sortKey="Sanderson, Jb" uniqKey="Sanderson J">JB Sanderson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, P" uniqKey="Liu P">P Liu</name></author><author><name sortKey="Ruhnke, M" uniqKey="Ruhnke M">M Ruhnke</name></author><author><name sortKey="Meersseman, W" uniqKey="Meersseman W">W Meersseman</name></author><author><name sortKey="Paiva, Ja" uniqKey="Paiva J">JA Paiva</name></author><author><name sortKey="Kantecki, M" uniqKey="Kantecki M">M Kantecki</name></author><author><name sortKey="Damle, B" uniqKey="Damle B">B Damle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wurthwein, G" uniqKey="Wurthwein G">G Wurthwein</name></author><author><name sortKey="Cornely, Oa" uniqKey="Cornely O">OA Cornely</name></author><author><name sortKey="Trame, Mn" uniqKey="Trame M">MN Trame</name></author><author><name sortKey="Vehreschild, Jj" uniqKey="Vehreschild J">JJ Vehreschild</name></author><author><name sortKey="Vehreschild, Mj" uniqKey="Vehreschild M">MJ Vehreschild</name></author><author><name sortKey="Farowski, F" uniqKey="Farowski F">F Farowski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stone, Ja" uniqKey="Stone J">JA Stone</name></author><author><name sortKey="Holland, Sd" uniqKey="Holland S">SD Holland</name></author><author><name sortKey="Wickersham, Pj" uniqKey="Wickersham P">PJ Wickersham</name></author><author><name sortKey="Sterrett, A" uniqKey="Sterrett A">A Sterrett</name></author><author><name sortKey="Schwartz, M" uniqKey="Schwartz M">M Schwartz</name></author><author><name sortKey="Bonfiglio, C" uniqKey="Bonfiglio C">C Bonfiglio</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nguyen, Th" uniqKey="Nguyen T">TH Nguyen</name></author><author><name sortKey="Hoppe Tichy, T" uniqKey="Hoppe Tichy T">T Hoppe-Tichy</name></author><author><name sortKey="Geiss, Hk" uniqKey="Geiss H">HK Geiss</name></author><author><name sortKey="Rastall, Ac" uniqKey="Rastall A">AC Rastall</name></author><author><name sortKey="Swoboda, S" uniqKey="Swoboda S">S Swoboda</name></author><author><name sortKey="Schmidt, J" uniqKey="Schmidt J">J Schmidt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Berl, T" uniqKey="Berl T">T Berl</name></author><author><name sortKey="Wilner, Kd" uniqKey="Wilner K">KD Wilner</name></author><author><name sortKey="Gardner, M" uniqKey="Gardner M">M Gardner</name></author><author><name sortKey="Hansen, Ra" uniqKey="Hansen R">RA Hansen</name></author><author><name sortKey="Farmer, B" uniqKey="Farmer B">B Farmer</name></author><author><name sortKey="Baris, Ba" uniqKey="Baris B">BA Baris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Garey, Kw" uniqKey="Garey K">KW Garey</name></author><author><name sortKey="Pai, Mp" uniqKey="Pai M">MP Pai</name></author><author><name sortKey="Suda, Kj" uniqKey="Suda K">KJ Suda</name></author><author><name sortKey="Turpin, Rs" uniqKey="Turpin R">RS Turpin</name></author><author><name sortKey="Rege, Md" uniqKey="Rege M">MD Rege</name></author><author><name sortKey="Mingo, De" uniqKey="Mingo D">DE Mingo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Voss, A" uniqKey="Voss A">A Voss</name></author><author><name sortKey="De Pauw, Be" uniqKey="De Pauw B">BE de Pauw</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>Belgique</li><li>Espagne</li><li>Finlande</li><li>France</li><li>Grèce</li><li>Italie</li><li>Royaume-Uni</li><li>Turquie</li></country><region><li>Angleterre</li><li>Attique (région)</li><li>Catalogne</li><li>Provence-Alpes-Côte d'Azur</li><li>Île-de-France</li></region><settlement><li>Athènes</li><li>Barcelone</li><li>Marseille</li><li>Paris</li></settlement></list><tree><country name="Australie"><noRegion><name sortKey="Sinnollareddy, Mahipal G" sort="Sinnollareddy, Mahipal G" uniqKey="Sinnollareddy M" first="Mahipal G" last="Sinnollareddy">Mahipal G. Sinnollareddy</name></noRegion><name sortKey="Koulenti, Despoina" sort="Koulenti, Despoina" uniqKey="Koulenti D" first="Despoina" last="Koulenti">Despoina Koulenti</name><name sortKey="Lipman, Jeffrey" sort="Lipman, Jeffrey" uniqKey="Lipman J" first="Jeffrey" last="Lipman">Jeffrey Lipman</name><name sortKey="Lipman, Jeffrey" sort="Lipman, Jeffrey" uniqKey="Lipman J" first="Jeffrey" last="Lipman">Jeffrey Lipman</name><name sortKey="Roberts, Jason A" sort="Roberts, Jason A" uniqKey="Roberts J" first="Jason A" last="Roberts">Jason A. Roberts</name><name sortKey="Roberts, Jason A" sort="Roberts, Jason A" uniqKey="Roberts J" first="Jason A" last="Roberts">Jason A. Roberts</name><name sortKey="Sinnollareddy, Mahipal G" sort="Sinnollareddy, Mahipal G" uniqKey="Sinnollareddy M" first="Mahipal G" last="Sinnollareddy">Mahipal G. Sinnollareddy</name><name sortKey="Sinnollareddy, Mahipal G" sort="Sinnollareddy, Mahipal G" uniqKey="Sinnollareddy M" first="Mahipal G" last="Sinnollareddy">Mahipal G. Sinnollareddy</name><name sortKey="Starr, Therese" sort="Starr, Therese" uniqKey="Starr T" first="Therese" last="Starr">Therese Starr</name><name sortKey="Wallis, Steven C" sort="Wallis, Steven C" uniqKey="Wallis S" first="Steven C" last="Wallis">Steven C. Wallis</name></country><country name="Turquie"><noRegion><name sortKey="Akova, Murat" sort="Akova, Murat" uniqKey="Akova M" first="Murat" last="Akova">Murat Akova</name></noRegion></country><country name="Italie"><noRegion><name sortKey="Bassetti, Matteo" sort="Bassetti, Matteo" uniqKey="Bassetti M" first="Matteo" last="Bassetti">Matteo Bassetti</name></noRegion></country><country name="Belgique"><noRegion><name sortKey="De Waele, Jan J" sort="De Waele, Jan J" uniqKey="De Waele J" first="Jan J" last="De Waele">Jan J. De Waele</name></noRegion></country><country name="Finlande"><noRegion><name sortKey="Kaukonen, Kirsi Maija" sort="Kaukonen, Kirsi Maija" uniqKey="Kaukonen K" first="Kirsi-Maija" last="Kaukonen">Kirsi-Maija Kaukonen</name></noRegion></country><country name="Grèce"><region name="Attique (région)"><name sortKey="Koulenti, Despoina" sort="Koulenti, Despoina" uniqKey="Koulenti D" first="Despoina" last="Koulenti">Despoina Koulenti</name></region><name sortKey="Dimopoulos, George" sort="Dimopoulos, George" uniqKey="Dimopoulos G" first="George" last="Dimopoulos">George Dimopoulos</name></country><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Martin, Claude" sort="Martin, Claude" uniqKey="Martin C" first="Claude" last="Martin">Claude Martin</name></region><name sortKey="Martin, Claude" sort="Martin, Claude" uniqKey="Martin C" first="Claude" last="Martin">Claude Martin</name><name sortKey="Montravers, Philippe" sort="Montravers, Philippe" uniqKey="Montravers P" first="Philippe" last="Montravers">Philippe Montravers</name></country><country name="Espagne"><region name="Catalogne"><name sortKey="Rello, Jordi" sort="Rello, Jordi" uniqKey="Rello J" first="Jordi" last="Rello">Jordi Rello</name></region></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Rhodes, Andrew" sort="Rhodes, Andrew" uniqKey="Rhodes A" first="Andrew" last="Rhodes">Andrew Rhodes</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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